2. Apoptosis
  3. Apoptosis
  4. Tetrazanbigen

Tetrazanbigen 是一种强效且选择性的抗肿瘤剂。Tetrazanbigen 对六种人癌细胞系表现出强大的抗肿瘤效力，IC50 范围为 2.13-8.01 μg/mL，对正常肝细胞的 IC50 为 11.25 μg/mL。Tetrazanbigen 可诱导 QGY-7701 细胞 S 期阻滞和凋亡 (apoptosis)。Tetrazanbigen 通过诱导癌细胞中的脂质积累来发挥抗肿瘤活性。

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Tetrazanbigen

Tetrazanbigen Chemical Structure

CAS No. : 2121990-04-1

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Tetrazanbigen 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetrazanbigen is a potent and selective antitumor agent. Tetrazanbigen exhibits strong antitumor efficacy against six human cancer cell lines with an IC50 range of 2.13-8.01 μg/mL and an IC50 of 11.25 μg/mL against normal hepatocytes. Tetrazanbigen induces S phase arrest and apoptosis in QGY-7701 cells. Tetrazanbigen exerts its antitumor activity by inducing lipid accumulation accumulation in cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
9.65 μM
Compound: TNBG; 8g
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 33423463]
HepG2 IC50
7.81 μM
Compound: TNBG; 8g
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 33423463]
LoVo IC50
8.92 μM
Compound: TNBG; 8g
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 33423463]
体外研究
(In Vitro)

Tetrazanbigen (0-12 μg/mL，72 小时) 抑制 QGY-7701 细胞、BIU-87 细胞、Hep-2 细胞、SGC-7901 细胞、K562 细胞、SW626 细胞和 LO2 细胞的增殖，IC50 值分别为 2.13 μg/mL、3.25 μg/mL、3.84 μg/mL、4.41 μg/mL、7.70 μg/mL、8.01 μg/mL 和 11.25 μg/mL[1]。

Tetrazanbigen (0-8 μg/mL，24-72 小时) 诱导 QGY-7701 细胞中的脂质积累[1]。

Tetrazanbigen (2-4 μg/mL, 72 小时) 诱导 QGY-7701 细胞周期停滞于 S 期并导致细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrazanbigen 相关抗体:

Cell Cycle Analysis[1]

Cell Line: QGY-7701 cells
Concentration: 2 μg/mL, 4 μg/mL
Incubation Time: 72 h
Result: Increased the population of S phase, decreased the populations of G0/G1 phases.

Apoptosis Analysis[1]

Cell Line: QGY-7701 cells
Concentration: 4 μg/mL
Incubation Time: 72 h
Result: Induced apoptosis, and caused condensed nuclei, apoptotic bodies and cellular shrinkage, chromatin margination.
Caused the appearance of a large number of lipid droplets.
体内研究
(In Vivo)

Tetrazanbigen (1.5 mg/kg/天，腹腔注射，5 周) 可抑制裸鼠体内的肿瘤生长且安全性较好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (Female athymic of 4 weeks old) bearing xenografts of QGY-7701 cell line (5 × 106, s.c.) [1]
Dosage: 1.5 mg/kg/day
Administration: i.p., 5 weeks
Result: Reduced tumor volume and inhibited tumor weight, the TGI based on tumor weight was 87%.
分子量

288.35

Formula

C18H16N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tetrazanbigen 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrazanbigen2121990-04-1TNBGApoptosisAntineoplastic AgentsQGY-7701 cellsNude miceXenografts of QGY-7701 cell lineInhibitorinhibitorinhibit

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