1. Immunology/Inflammation
  2. CD20
  3. TG20

TG20 是一种抗 CD20 单克隆抗体,可与 CD20 上特定的不连续表位结合,Kd 为 10-20 nM。TG20 具有增强的抗体依赖性细胞毒性 (ADCC)。TG20 可增强补体依赖性细胞毒性 (CDC) 活性。TG20 可用于 B 细胞淋巴瘤的研究。

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TG20

TG20 Chemical Structure

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TG20 is an anti-CD20 monoclonal antibody that binds to a specific discontinuous epitope on CD20 with a Kd of 10–20 nM. TG20 exhibits enhanced antibody-dependent cellular cytotoxicity (ADCC). TG20 also enhances complement-dependent cytotoxicity (CDC) activity. TG20 can be used in research on B-cell lymphomas [1].

反应种属

Human

IC50 & Target

CD20/MS4A1

体外研究
(In Vitro)

TG20 与 CD20 上的特定不连续表位有很强的结合力 (Kd = 10-20 nM)[1]
TG20 与 Rituximab (HY-P9913) 相比,激活表达 FcγRIIIa 受体 (CD16a) 的效应细胞能力显著增强[1]
TG20 与 Rituximab 相比,在 CD20+ Raji 细胞和 BCLL 来源的原代 B 细胞中显示增强的 抗体依赖性细胞介导的细胞毒性 (TG20 EC50 = 3.6 ng/mL,Rituximab EC50 = 59.4 ng/mL)[1]
TG20 与 Rituximab 相比,在 WIL2-S 细胞中的补体依赖性细胞毒性活性提高了 50% 以上 (TG20 的 CDC 活性为 170%,Rituximab 为 100%)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

基因 ID

931  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
TG20
目录号:
HY-P991904
需求量: