2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. TGF-8027

TGF-8027 是一种选择性 5-HT2A 受体激动剂，能够穿过血脑屏障。TGF-8027 对人 5-HT2A、5-HT2C 和 5-HT2B 受体的 EC50 值分别为 3.3 nM、160 nM 和 7600 nM，对小鼠 5-HT2A 和 5-HT2C 受体的 EC50 值分别为 14 nM 和 210 nM。TGF-8027 可诱导小鼠出现摇头反应。TGF-8027 可用于研究靶向 5-HT2A 受体的疾病 (如抑郁症)。

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TGF-8027

TGF-8027 Chemical Structure

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TGF-8027 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGF-8027 is a selective 5-HT2A agonist that can cross the blood-brain barrier. TGF-8027 exhibits EC50s of 3.3 nM, 160 nM and 7600 nM against human 5-HT2A, 5-HT2C and 5-HT2B and exhibits EC50s against mouse 5-HT2A and mouse 5-HT2C of 14 and 210 nM. TGF-8027 can induce a head-shaking response in mice. TGF-8027 can be used to study diseases that target the 5-HT2A receptor (such as depression)[1].

IC50 & Target[1]

5-HT2A Receptor

3.3 nM (EC50)

5-HT2C Receptor

160 nM (EC50)

5-HT2B Receptor

7600 nM (EC50)

体内研究
(In Vivo)

TGF-8027 (0.4-40 mg/kg，皮下注射，单次剂量) 以剂量依赖的方式诱导小鼠产生摇头反应，EC50 为 1.86 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Head-twitch response (HTR) model established in C57BL/6J mice[1]
Dosage: 0.4, 1.33, 4, 13.33 and 40 mg/kg
Administration: Subcutaneous injection (s.c.), single dose
Result: Induced a head-shaking response in mice in a dose-dependent manner.
分子量

326.39

Formula

C19H22N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGF-8027 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGF-8027TGF8027TGF 80275-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2A receptorstructure-based drug designselective agonisthead-twitch response (HTR)Inhibitorinhibitorinhibit

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目录号：
HY-178760
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