2. PI3K/Akt/mTOR
  3. PI3K
  4. TGX-115

TGX-115 是一种 p110β/p110δ 选择性的 PI3-K 抑制剂。TGX-115 阻断 p110β 介导的由溶血磷脂酸 (LPA) 诱导的 L6 肌管细胞中 Akt 磷酸化，降低 3T3-L1 脂肪细胞中胰岛素刺激的 PI(3,4)P2 和 PIP3 水平。TGX-115 可用于糖尿病研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TGX-115

TGX-115 Chemical Structure

CAS No. : 351071-62-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3102
In-stock
5 mg 询价 询价
10 mg 询价 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

TGX-115 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2].

IC50 & Target[1][2]

p110β

 

p110δ

 

体外研究
(In Vitro)

TGX-115 (0.1-10 μM, 6 h) 阻断 U373MG 胶质瘤细胞中的 Akt (Ser473) 磷酸化，但对 Erk (Thr202/204) 磷酸化无剂量依赖性影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TGX-115 相关抗体:
体内研究
(In Vivo)

TGX-115 (10 mg/kg，腹腔注射，单剂量) 对 4 个月龄 FVB/N 雌性小鼠中胰岛素诱导的血糖降低无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

336.38

Formula

C20H20N2O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

TGX-115 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGX-115351071-62-0TGX115TGX 115PI3KPhosphoinositide 3-kinaseAkt/mTOR signalingisomerplatelet adhesivenesscardiovascular diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TGX-115
目录号：
HY-124535
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z