2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Thailanstatin B

Thailanstatin B  (Synonyms: 泰兰斯他汀B)

目录号: HY-139102
产品使用指南 技术支持

Thailanstatin B 是一种有效的 pre-mRNA 剪接抑制剂 (IC50=6.18 μM)。Thailanstatin B 具有抗增殖活性。

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Thailanstatin B

Thailanstatin B Chemical Structure

CAS No. : 1426953-23-2

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Thailanstatin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thailanstatin B is a potent pre-mRNA splicing inhibitor (IC50=6.18 μM). Thailanstatin B shows antiproliferative activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-474 IC50
> 100 nM
Compound: 10
Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay
Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay
[PMID: 25098528]
DU-145 GI50
3 nM
Compound: 2
Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay
[PMID: 23517093]
HEK-293T IC50
193.7 nM
Compound: 6
Cytotoxicity against HEK293T cells assessed as inhibition in cell growth
Cytotoxicity against HEK293T cells assessed as inhibition in cell growth
[PMID: 33974423]
HEK293 IC50
6.18 μM
Compound: 2
Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay
Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay
[PMID: 23517093]
MDA-MB-231 GI50
6.22 nM
Compound: 2
Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay
[PMID: 23517093]
MDA-MB-468 IC50
> 100 nM
Compound: 10
Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay
Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay
[PMID: 25098528]
MES-SA IC50
856.3 nM
Compound: 6
Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth
Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth
[PMID: 33974423]
MES-SA/Dx5 IC50
> 1000 nM
Compound: 6
Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth
Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth
[PMID: 33974423]
NCI-N87 IC50
> 100 nM
Compound: 10
Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay
Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay
[PMID: 25098528]
SK-OV-3 GI50
4.94 nM
Compound: 2
Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay
[PMID: 23517093]
体外研究
(In Vitro)

Thailanstatin B 对 DU-145、NCI-H232A、MDA-MB-231 和 SKOV-3 细胞表现出强效抗增殖活性，GI50s 为 2.5-4.94 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thailanstatin B 相关抗体:
分子量

572.09

Formula

C28H42ClNO9
CAS 号
中文名称

泰兰斯他汀B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thailanstatin B 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thailanstatin B1426953-23-2泰兰斯他汀BDNA/RNA Synthesispre-mRNAsplicingantiproliferativecancerInhibitorinhibitorinhibit

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目录号：
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