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TK-112690  (Synonyms: 2,2-脱水-5-甲基尿苷)

目录号: HY-W008491 纯度: 99.0%
COA 产品使用指南 技术支持

TK-112690 是一种 UPP1 抑制剂。TK-112690 在体外抑制小鼠小肠脲苷磷酸化酶（UPase）的 IC50 为 12.5 μM，抑制人小肠 UPase 的 IC50 为 20.0 μM。TK-112690 可增加小鼠血浆中脲苷的浓度。TK-112690 可用于癌症和肺纤维化的研究。

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TK-112690

TK-112690 Chemical Structure

CAS No. : 22423-26-3

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规格 价格 是否有货 数量
10 g ￥156
In-stock
25 g ￥281
In-stock
50 g ￥438
In-stock
100 g ￥688
In-stock
500 g ￥1656
In-stock
1 kg ￥2625
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Customer Review

TK-112690 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC50 of 12.5 μM and human small intestinal UPase with an IC50 of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis[1][2][3].

体内研究
(In Vivo)

TK-112690 (10-30 mg/kg，腹腔注射，methotrexate (HY-14519) 前后3小时，在第2-3天，持续4周) 可减轻 LPS (HY-D1056) 处理的 C57BL/6 小鼠中甲氨蝶呤 (MTX) 引起的体重减轻[2]。
TK-112690 (60 mg/kg，腹腔注射，MTX 前后3小时，在第2-4天，持续7天) 可减少 C57BL/6 雌性小鼠中 MTX 引起的粘膜通透性损失[2]。
TK-112690 (120 mg/kg，腹腔注射，给药后0.08-12小时检测) 可增加 CD-1 雌性小鼠血浆中脲苷浓度[2]。
TK-112690 (667-3000 mg/kg/天，通过渗透泵连续皮下输注24-72小时) 以线性方式提高 BDF-1 小鼠血浆中脲苷 (UR) 浓度[3]。
TK-112690 (60 mg/kg，腹腔注射，每日两次，间隔6-8小时，在第7-20天) 可减少 Bleomycin (HY-108345) 诱导的 C57BL/6 小鼠肺纤维化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 10, 30 mg/kg
Administration: i.p., 3 h before and after methotrexate (HY-14519) on Days 2-3, 4 weeks
Result: Mitigated MTX-induced weight loss in LPS-treated C57BL/6 mice.
Animal Model: C57BL/6 mice[2]
Dosage: 120 mg/kg
Administration: i.p., detected at 0.08-12 h post-dose
Result: Reduced MTX-induced mucosal permeability loss in C57BL/6 female mice.
Animal Model: CD-1 female mice[2]
Dosage: 120 mg/kg
Administration: i.p., detected at 0.08-12 h post-dose
Result: Increased plasma uridine concentration in CD-1 female mice.
Animal Model: BDF-1 mice[3]
Dosage: 667, 833, 3000 mg/kg/day
Administration: s.c. infusion via osmotic pumps for 24-72 h
Result: Elevated plasma uridine (UR) concentration in a linear manner in BDF-1 mice.
Animal Model: C57BL/6 mice[3]
Dosage: 60 mg/kg
Administration: i.p., twice daily with 6-8 h interval on Days 7-20
Result: Reduced pulmonary fibrosis in C57BL/6 mice with Bleomycin (HY-108345)-induced fibrosis.
分子量

240.21

Formula

C10H12N2O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

2,2-脱水-5-甲基尿苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.0%

COA (289 KB) HNMR (132 KB)

产品使用指南 (1538 KB)
参考文献

TK-112690 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK-11269022423-26-32,2-脱水-5-甲基尿苷TK112690TK 112690OthersUPP1UPasecancerpulmonary fibrosisInhibitorinhibitorinhibit

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