2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR2/1 agonist-1

TLR2/1 agonist-1 是一种 TLR2/1 异二聚体选择性激动剂。TLR2/1 agonist-1 可作为造血恢复诱导剂，加速外周血细胞恢复。TLR2/1 agonist-1 可作为 G-CSF 产生诱导剂，提升血清 G-CSF 水平。TLR2/1 agonist-1 对暴露于射线的小鼠具有辐射防护作用。TLR2/1 agonist-1 可用于急性放射综合征的相关研究。

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TLR2/1 agonist-1

TLR2/1 agonist-1 Chemical Structure

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TLR2/1 agonist-1 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLR2/1 agonist-1 is a selective agonist of the TLR2/1 heterodimer. TLR2/1 agonist-1 acts as a hematopoietic recovery inducer to accelerate the recovery of peripheral blood cells. TLR2/1 agonist-1 serves as a G-CSF production inducer to increase serum G-CSF levels. TLR2/1 agonist-1 exhibits radioprotective effects in mice exposed to radiation. TLR2/1 agonist-1 can be used in studies related to acute radiation syndrome[1].

IC50 & Target[1]

TLR2

 

TLR1

 

体外研究
(In Vitro)

TLR2/1 agonist-1 (Compound H9) (10 μM) 可在瞬时共转染的 HEK 293 T 细胞中显著激活 TLR2/1 信号通路，其 RLU 倍数为 1.674[1]。
TLR2/1 agonist-1 (0.001-10 μM) 可在 PMA (HY-18739) 分化的 THP-1 细胞中剂量依赖性地上调 TLR2 和 TLR1 的表达，但不影响 TLR6 的表达[1]。
TLR2/1 agonist-1 (10 μM) 可在 PMA 分化的 THP-1 细胞中特异性促进 TLR2/1 复合物的异源二聚化，而非 TLR2/6 复合物[1]。
TLR2/1 agonist-1 (10 μM) 可直接结合 TLR2/1 异源二聚体，增强经 PMA 分化的 THP-1 细胞中 TLR2 与 TLR1 蛋白的热稳定性[1]。
TLR2/1 agonist-1 (0.01-10 μM) 可剂量依赖性地刺激经 PMA 分化的 THP-1 细胞分泌 IL-6，证实其可激活下游 TLR2/1 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLR2/1 agonist-1 相关抗体:
体内研究
(In Vivo)

TLR2/1 agonist-1 (30-80 mg/kg，腹腔注射，于照射前 24 h 和 30 min 给药) 可使暴露于 8.5 Gy 60Co γ 射线的雄性 C57BL/6 J 小鼠获得 100% 的 30 天存活率，且体重恢复速度快于对照组[1]。
TLR2/1 agonist-1 (60 mg/kg；腹腔注射；照射前 24 h 及 30 min) 可促进接受 6.5 Gy 60Co γ 射线照射的雄性 C57BL/6 J 小鼠外周血中 WBC、RBC、HGB 及 PLT 计数的恢复，且在照射后多个时间点的水平均显著高于对照组[1]。
TLR2/1 agonist-1 (80 mg/kg；腹腔注射；辐射前 24 h 和 30 min) 可显著提升受辐照雄性 C57BL/6 J 小鼠的外周血 G-CSF 水平，其水平约为未受辐照对照小鼠的 14 倍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (male, exposed to 8.5 Gy of 60Co γ-rays)[1]
Dosage: 80 mg/kg; 60 mg/kg; 30 mg/kg
Administration: i.p.; 24 h and 30 min before radiation
Result: Achieved a 100% 30-day survival rate at 80 mg/kg and 60 mg/kg.
Achieved a 20% 30-day survival rate at 30 mg/kg.
Showed the fastest body weight recovery among drug treatment groups after an initial post-radiation decrease at 80 mg/kg.
Animal Model: C57BL/6 J (male, exposed to 6.5 Gy of 60Co γ-rays)[1]
Dosage: 60 mg/kg
Administration: i.p.; 24 h and 30 min before radiation
Result: Exhibited significantly higher WBC count than the control group on days 18 and 22 post-irradiation, with faster recovery after the nadir on day 4.
Showed significantly higher RBC count than the control group on days 14 and 18 post-irradiation, returning to normal levels by day 18 (vs. day 22 for the control group).
Had significantly higher HGB levels than the control group on days 14 and 18 post-irradiation, with faster recovery after the nadir on day 14.
Demonstrated significantly higher PLT count than the control group on days 14, 18, and 22 post-irradiation, with recovery after the nadir on day 10.
Animal Model: C57BL/6 J (male, exposed to 60Co γ-rays)[1]
Dosage: 80 mg/kg
Administration: i.p.; 24 h and 30 min before radiation
Result: Caused a sharp increase in peripheral blood G-CSF levels, which were approximately 14-fold higher than levels in unirradiated control mice and significantly elevated compared to irradiated control mice.
分子量

338.29

Formula

C17H11FN4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLR2/1 agonist-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

TLR2/1 agonist-1Toll-like Receptor (TLR)HEK 293 T cellshematopoietic recoveryTLR2/1 heterodimerG-CSFmiceTHP-1 cellsPMA-differentiated THP-1 cellsacute radiation syndromeTLR1TLR2Inhibitorinhibitorinhibit

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