2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Fc Receptor (FcR)
  4. TNX-1500

TNX-1500 是一种可结晶片段修饰的抗 CD154 抗体。TNX-1500 包含来自 Ruplizumab (HY-P99315) 的 hu5c8 片段抗原结合 (Fab) 结构域以及经过工程改造以降低 FcγRIIa 结合的 IgG4 Fc 区域。与 hu5c8 相比，TNX-1500 对 FcγRI、FcγRIIaH、FcγRIIbF、FcγRIIIaF 和 FcγRIIIaV 的结合亲和力显著较弱 (Kd 值分别为 8.7 nM、7100 nM、4900 nM、8000 nM、6000 nM)。TNX-1500 可延长非人灵长类动物肾同种异体移植物的存活时间，延长非人灵长类动物心脏同种异体移植物的存活时间。TNX-1500 可用于同种异体移植物排斥反应的研究。

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TNX-1500

TNX-1500 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

TNX-1500 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection[1][2].

反应种属

Human
IC50 & Target[1]

CD40L

 

FcγRI

8.7 nM (Kd)

FcγRIIaH

7100 nM (Kd)

FcγRIIbF

4900 nM (Kd)

FcγRIIIaF

8000 nM (Kd)

FcγRIIIaV

6000 nM (Kd)

体外研究
(In Vitro)

TNX-1500 (500 nM) 与 sCD154 复合后，在食蟹猴或人全血中不会诱导血小板活化[1]。
与 hu5c8 相比，TNX-1500 对 FcγRI、FcγRIIaH、FcγRIIbF、FcγRIIIaF 和 FcγRIIIaV 的结合亲和力显著更弱 (KD 值分别为 8.7 nM、7100 nM、4900 nM、8000 nM、6000 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNX-1500 相关抗体:
体内研究
(In Vivo)

TNX-1500 (20 mg/kg；静脉注射；第 0、2、5、12 天给药，随后每周给药持续 6 个月；或第 0、2、5、12 天给药，随后每周给药持续 6 周，之后每 2 周给药一次直至第 180 天) 可维持 MHC 错配、ABO 血型相合的食蟹猴肾移植模型的肾移植物存活 (180 天时存活率为 83%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

959  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNX-1500 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNX-1500TNX1500TNX 1500TNF ReceptorFc Receptor (FcR)Tumor Necrosis Factor ReceptorTNFRFc ReceptorFcγRIIIaFallograft rejectionFcγRIIIaVcynomolgus monkeyantidonor alloantibody elaborationnonhuman primatesplateletsTEFF/TREG ratioFcγRIIaHCD40cardiac allograft vasculopathyregulatory T cellssCD154kidney transplantationchronic rejectionFcγRICAVnonhuman primate heart allotransplant modelshuman whole bloodABO blood type-compatibleCD154FcγRIIbFeffector T cellskidney allograft rejectionT cell costimulation pathwaysMHC-mismatchedInhibitorinhibitorinhibit

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目录号：
HY-P991921
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