2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. TPα/β antagonist-1

TPα/β antagonist-1 是一种 TXA2 受体 α (TPα) 和 TPβ 拮抗剂，其 IC50 值分别为 1.52 nM 和 0.79 nM。TPα/β antagonist-1 可抑制 U-46619 (HY-108566) 诱导的细胞内钙离子动员，并抑制血小板聚集。TPα/β antagonist-1 可用于心血管疾病的研究。

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TPα/β antagonist-1

TPα/β antagonist-1 Chemical Structure

CAS No. : 899789-84-5

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TPα/β antagonist-1 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPα/β antagonist-1 is a TXA2 receptor α (TPα) and TPβ antagonist with IC50s of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits U-46619 (HY-108566)-induced intracellular calcium mobilization, and imhibits platelet aggregation. TPα/β antagonist-1 can be used for the research of cardiovascular disease[1].

IC50 & Target

TPα

1.52 nM (IC50)

体外研究
(In Vitro)

TPα/β antagonist-1 (compound 7d) 可与 TPα 和 TPβ 受体结合，且对 TPβ 的亲和力更强 (IC50 TPα = 1.52 nM，IC50 TPβ = 0.79 nM)[1]。
TPα/β antagonist-1 可拮抗 U-46619 (HY-108566) 介导的钙动员，且对 TPβ 的效力更强 (TPα 的 IC50 为 600.71 nM，TPβ 的 IC50 为 70.15 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TPα/β antagonist-1 相关抗体:
分子量

433.48

Formula

C20H23N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPα/β antagonist-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPα/β antagonist-1899789-84-5Prostaglandin Receptorplatelet aggregationTPαstrokemyocardial infarctionU46619atherosclerosisTPα receptorsTPβTPβ receptorshuman platelet-rich plasmaintracellular calcium mobilizationInhibitorinhibitorinhibit

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产品名称：
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HY-186042
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