2. Immunology/Inflammation
  3. TREM receptor
  4. TREM2 agonist-5

TREM2 agonist-5 是小胶质细胞脂质感应受体 (TREM2) 激动剂，其 Kd 为 71.36 μM。TREM2 agonist-5 是 TREM2 激动剂 VG-3927 的外消旋结构类似物，在 HEK293-hTREM2/DAP12 细胞中表现出优异的小胶质细胞吞噬作用，并可激活 TREM2 信号传导。TREM2 agonist-5 的体外药代动力学特征优于 VG-3927。TREM2 agonist-5 可用于阿尔茨海默病的研究。

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TREM2 agonist-5

TREM2 agonist-5 Chemical Structure

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TREM2 agonist-5 相关抗体

Top Publications Citing Use of Products

查看 TREM receptor 亚型特异性产品:

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TREM-1 TREM-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease[1].

IC50 & Target[1]

TREM-2

71.36 μM (Kd)

体外研究
(In Vitro)

TREM2 agonist-5 (Compound C1) 表现出优于 VG-3927 的体外药代动力学特征：在人和小鼠肝微粒体中增强的代谢稳定性、良好的被动通透性 (PAMPA) 和中枢神经系统 (CNS) 兼容的 log D7.4[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TREM2 agonist-5 相关抗体:
分子量

449.91

Formula

C24H21ClFN5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TREM2 agonist-5 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TREM2 agonist-5TREM receptorTriggering receptors expressed on myeloid cellsTREM2Alzheimer’s diseaseDrug discoveryPharmacokineticsComputational chemistryInhibitorinhibitorinhibit

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