2. Immunology/Inflammation NF-κB JAK/STAT Signaling Stem Cell/Wnt Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Toll-like Receptor (TLR) NF-κB STAT MMP COX VEGFR
  4. TU-100

TU-100 是一种日本中药。TU-100 通过调节肿瘤微环境 (TME) 中的癌相关成纤维细胞 (CAFs) 发挥抗癌作用。TU-100 可通过抑制 TLR4/NF-κB/STAT3 轴，拮抗肿瘤微环境中巨噬细胞的 M2 极化表型。TU-100 能抑制肿瘤相关巨噬细胞 (TAMs) 中 MMP-2、COX-2 和 VEGF 的高表达。

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TU-100

TU-100 Chemical Structure

CAS No. : 1310907-71-1

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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TU-100 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TU-100 is a Japanese herbal medicine. TU-100 exhibits anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. TU-100 can antagonize the M2 polarization phenotype of macrophages in the tumor microenvironment by suppressing the TLR4/NF-κB/STAT3 axis. TU-100 can inhibit the high expression of MMP-2, COX-2, and VEGF in TAMs[1].

IC50 & Target[1]

TLR4

 

STAT3

 

MMP-2

 

COX-2

 

分子量

315.32

Formula

C20H13NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TU-100 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TU-1001310907-71-1TU100TU 100Toll-like Receptor (TLR)NF-κBSTATMMPCOXVEGFRNuclear factor-κBNuclear factor-kappaBMatrix metalloproteinasesCyclooxygenaseVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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