1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin polymerization-IN-33

Tubulin polymerization-IN-33 是一种 [1,2] 恶唑洛异吲哚微管蛋白聚合的抑制剂,对 NCI 系列癌细胞具有高抗增殖活性。

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Tubulin polymerization-IN-33

Tubulin polymerization-IN-33 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-33 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, exhibits high antiproliferative activity against the NCI panel[1].

IC50 & Target

[1,2]oxazoloisoindoles tubulin polymerization[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
0.36 μM
Compound: 15k
Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
A498 GI50
0.28 μM
Compound: 15k
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
A549 GI50
0.42 μM
Compound: 15k
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
ACHN GI50
0.62 μM
Compound: 15k
Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
BT-549 GI50
0.49 μM
Compound: 15k
Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
CCRF-CEM GI50
0.32 μM
Compound: 15k
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
COLO 205 GI50
0.3 μM
Compound: 15k
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
DU-145 GI50
0.39 μM
Compound: 15k
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
EKVX GI50
0.51 μM
Compound: 15k
Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HBL1 IC50
1.7 μM
Compound: 15k
Antiproliferative activity against human HBL1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HBL1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 36242921]
HCC 2998 GI50
1.34 μM
Compound: 15k
Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HCT-116 GI50
0.27 μM
Compound: 15k
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HCT-15 GI50
0.26 μM
Compound: 15k
Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HL-60(TB) GI50
0.21 μM
Compound: 15k
Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HOP-92 GI50
3.39 μM
Compound: 15k
Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
HT-29 GI50
0.32 μM
Compound: 15k
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
Hs-578T GI50
0.41 μM
Compound: 15k
Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
IGROV-1 GI50
0.49 μM
Compound: 15k
Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
KM12 GI50
0.27 μM
Compound: 15k
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
LOX IMVI GI50
0.57 μM
Compound: 15k
Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
M14 GI50
0.15 μM
Compound: 15k
Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
MCF7 GI50
0.09 μM
Compound: 15k
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
MDA-MB-231 GI50
0.63 μM
Compound: 15k
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
MDA-MB-435 GI50
0.03 μM
Compound: 15k
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
MDA-MB-468 GI50
0.33 μM
Compound: 15k
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
MOLT-4 GI50
0.44 μM
Compound: 15k
Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
Malme-3M GI50
13.5 μM
Compound: 15k
Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI-H226 GI50
15 μM
Compound: 15k
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI-H23 GI50
0.52 μM
Compound: 15k
Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI-H322M GI50
0.64 μM
Compound: 15k
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI-H460 GI50
0.34 μM
Compound: 15k
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI-H522 GI50
0.15 μM
Compound: 15k
Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
NCI/ADR-RES GI50
0.26 μM
Compound: 15k
Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
OVCAR-3 GI50
0.22 μM
Compound: 15k
Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
OVCAR-4 GI50
5.44 μM
Compound: 15k
Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
OVCAR-5 GI50
0.71 μM
Compound: 15k
Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
OVCAR-8 GI50
0.38 μM
Compound: 15k
Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
PC-3 GI50
0.27 μM
Compound: 15k
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
RPMI-8226 GI50
0.42 μM
Compound: 15k
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
RXF 393 GI50
0.16 μM
Compound: 15k
Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SF-268 GI50
1.06 μM
Compound: 15k
Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SF-295 GI50
0.18 μM
Compound: 15k
Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SF-539 GI50
0.23 μM
Compound: 15k
Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SK-MEL-2 GI50
0.46 μM
Compound: 15k
Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SK-MEL-28 GI50
3.6 μM
Compound: 15k
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SK-MEL-5 GI50
0.21 μM
Compound: 15k
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SK-OV-3 GI50
0.37 μM
Compound: 15k
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SN12C GI50
0.72 μM
Compound: 15k
Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SNB-19 GI50
0.39 μM
Compound: 15k
Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SNB-75 GI50
0.18 μM
Compound: 15k
Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SR GI50
0.21 μM
Compound: 15k
Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
SU-DHL10 IC50
1.8 μM
Compound: 15k
Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 36242921]
SW-620 GI50
0.37 μM
Compound: 15k
Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
TK-10 GI50
17.7 μM
Compound: 15k
Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
U-251 GI50
0.33 μM
Compound: 15k
Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
UACC-257 GI50
14.7 μM
Compound: 15k
Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
UACC-62 GI50
0.25 μM
Compound: 15k
Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
UO-31 GI50
0.58 μM
Compound: 15k
Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36242921]
体外研究
(In Vitro)

Tubulin polymerization-IN-33 (compound 15K) (10 nM-100 μM; 72 h) has antiproliferative activity against 9 NCI subpanels (leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, breast) with GI50s ranging from 0.03 μM to 17.7 μM, and a mean graph_mid point (MG_MID) values of 0.49 μM[1].
Tubulin polymerization-IN-33 (0.15-10 μM; 72 h) shows potent growth inhibitory effects on different lymphoma lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Marginal zone lymphoma, mantle cell lymphoma, activated B-cell like diffuse large B cell lymphoma, germinal center B-cell-like diffuse large B cell lymphoma cells
Concentration: 0.15-10 μM
Incubation Time: 72 h
Result: Inhibited different lymphomas, with IC50s of 1.6 μM (Marginal zone lymphoma); 1.4 μM (mantle cell lymphoma); 1.7 μM (activated B-cell like diffuse large B cell lymphoma); 1.8 μM (germinal center B-cell-like diffuse large B cell lymphoma), respectively.
分子量

476.52

Formula

C27H28N2O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tubulin polymerization-IN-33
目录号:
HY-151394
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