2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-65

Tubulin polymerization-IN-65 是一种微管蛋白聚合 (tubulin polymerisation) 抑制剂，具有广谱的细胞毒性。Tubulin polymerization-IN-65 诱导 G2 + M 细胞周期停滞。

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Tubulin polymerization-IN-65

Tubulin polymerization-IN-65 Chemical Structure

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Tubulin polymerization-IN-65 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 GI50
0.33 μM
Compound: 64
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
A2780 GI50
0.33 μM
Compound: 64
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
A549 IC50
> 25 μM
Compound: 4
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
BE(2)-C GI50
0.31 μM
Compound: 64
Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
DU-145 GI50
0.9 μM
Compound: 64
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
HCT-116 IC50
1.46 μM
Compound: 4
Antiproliferative activity against p53-/- human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against p53-/- human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
HCT-116 IC50
1.58 μM
Compound: 5b
Cytotoxicity against human HCT116 cells after 24 to 96 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 24 to 96 hrs by MTS assay
[PMID: 20303768]
HCT-116 IC50
2.47 μM
Compound: 4
Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
HT-29 GI50
0.26 μM
Compound: 64
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MCF-10A GI50
0.56 μM
Compound: 64
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MCF7 GI50
0.35 μM
Compound: 64
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MCF7 IC50
4.45 μM
Compound: 4
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
MIA PaCa-2 GI50
0.37 μM
Compound: 64
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
NCI-H460 GI50
0.42 μM
Compound: 64
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
NHDF IC50
> 25 μM
Compound: 4
Antiproliferative activity against human NHDF cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human NHDF cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
NIH3T3 IC50
1.17 μM
Compound: 5b
Cytotoxicity against mouse NIH/3T3 cells assessed as viable cells after 72 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as viable cells after 72 hrs by MTT assay
[PMID: 20303768]
SK-N-MC IC50
2.88 μM
Compound: 5b
Cytotoxicity against human SK-N-MC cells after 72 hrs by MTT assay
Cytotoxicity against human SK-N-MC cells after 72 hrs by MTT assay
[PMID: 20303768]
U-87MG ATCC GI50
1.4 μM
Compound: 64
Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
体外研究
(In Vitro)

Tubulin polymerization-IN-65（化合物 64；5 μM；24 小时）诱导 G2 + M 细胞周期停滞[1]。
Tubulin polymerization-IN-65 (72 小时) 抑制 HT29、U87、MC-7、A2780、H460、A431、Du145、BE2-C、SJ-G2、MIA、MCF10A 的细胞生长，GI50 分别为 0.26 μM、1.4 μM、0.35 μM、0.33 μM、0.42 μM、0.33 μM、0.90 μM、0.31 μM、0.79 μM、0.37 μM 和 0.56 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-65 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MIA pancreatic cancer cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Induced G2 + M cell cycle arrest.
分子量

278.31

Formula

C17H14N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-65 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-65Microtubule/Tubulintubulin polymerisation inhibitorsub micromolar cytotoxicityG2 + M cell cycle arrestInhibitorinhibitorinhibit

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