2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. UK122 hydrochloride

UK122 hydrochloride 是一种强效的，选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，IC50 为 0.2 μM。UK122 hydrochloride 对组织型 PA (tPA)、纤溶酶、凝血酶和胰蛋白酶没有或几乎没有抑制作用 (IC50 均 > 100 μM)。UK122 hydrochloride 是 4- 恶唑烷酮类似物，一种抗癌剂，可抑制癌细胞迁移和侵袭。

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UK122 hydrochloride

UK122 hydrochloride Chemical Structure

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规格 价格 是否有货 数量
5 mg ￥2200
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10 mg ￥3500
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Other Forms of UK122 hydrochloride:

UK122 hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].

体外研究
(In Vitro)

UK122 (11.1-100 μM；24 小时) hydrochloride 剂量依赖性地抑制细胞迁移并显著降低 CFPAC-1 细胞的侵袭性[1]。
UK122 (10-100 μM；48 小时) hydrochloride 对 CFPAC-1 细胞中的任何细胞生长或细胞形态变化均无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UK122 hydrochloride 相关抗体:
分子量

327.76

Formula

C17H14ClN3O2
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

UK122 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK122UK 122UK-122Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesurokinase-typeplasminogenuPAtPAplasminthrombintrypsinmigratioinvasionCFPAC-1pancreaticInhibitorinhibitorinhibit

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产品名称：
UK122 hydrochloride
目录号：
HY-111056A
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