2. 抗体抑制剂
  3. Biosimilar 抗体
  4. 单克隆抗体
  5. Unasnemab

Unasnemab  (Synonyms: MT-3921; rH116A3)

目录号: HY-P99959 纯度: 99.00%
COA 技术支持

Unasnemab (MT-3921) 是一种人源化 IgG1 单克隆抗体，结合排斥引导分子 A (RGMa)。Unasnemab 改善运动功能并促进神经再生。Unasnemab 对 db/db 小鼠、Streptozotocin (STZ) (HY-13753) 诱导的 1 型糖尿病小鼠以及双侧颈总动脉狭窄 (BCAS) 诱导的小鼠的海马神经发生障碍和认知功能下降具有改善作用。Unasnemab 可用于研究脊髓损伤和糖尿病诱发的神经功能障碍。

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CAS No. : 2379805-59-9

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规格 价格 是否有货 数量
1 mg ￥3000
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Unasnemab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Unasnemab (MT-3921) is a humanised IgG1 monoclonal antibody that binds to repulsive guidance molecule A (RGMa). Unasnemab improves locomotor function and promotes neuroregeneration. Unasnemab exerts ameliorative effects on hippocampal neurogenesis impairment and cognitive decline in db/db mice, Streptozotocin (STZ) (HY-13753)-induced type 1 diabetic and bilateral common carotid artery stenosis (BCAS)-induced mice. Unasnemab can be used for the research of spinal cord injury, diabetes-induced neurological impairments[1][2][3].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

RGMA
体外研究
(In Vitro)

Unasnemab (48 h) 以剂量依赖性方式显著缓解了与表达 Tax 的 JPX9 细胞共培养的 NB-1 人神经元细胞平均神经突长度的减少[1]。
Unasnemab (0.001-10 μg/mL, 72 h) 以剂量依赖性方式显著逆转了与 HTLV-1 相关性脊髓病 (HAM) 外周血单核细胞 (PBMCs) 共培养的 NB-1 细胞培养基中神经丝轻链 (NF-L) 浓度的增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Unasnemab 相关抗体:
体内研究
(In Vivo)

Unasnemab (30 mg/kg, 静脉注射, 每周一次, 6 周) 对 db/db 小鼠和 Streptozotocin (STZ) (HY-13753) 诱导的 1 型糖尿病小鼠的海马神经发生障碍和认知功能下降具有改善作用[2]。
Unasnemab (10 mg/kg, 腹腔注射, 每周两次, 从手术后第 3 天开始，共 9 次注射) 显著改善双侧颈总动脉狭窄 (BCAS) 诱导的小鼠病理变化和认知缺陷[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old db/db mice (type 2 diabetes model) and STZ-induced type 1 diabetic 8-week-old C57BL/6JJmsSlc mice[2]
Dosage: 30 mg/kg
Administration: i.v., once weekly, 6 weeks
Result: Increased the number and density of DCX-positive immature neurons in the hippocampal granular cell layer (GCL), and improved their morphological defects.
Significantly increased the Discrimination Index (DI) in both Novel Object Recognition Test (NORT) and Object Placement Test (OPT) to restore hippocampus-dependent memory.
Showed no significant effects on STZ-induced body weight loss and blood glucose elevation.
Animal Model: Adult male C57BL/6J mice (8-10 weeks old) were used to establish the vascular dementia (VaD) model via bilateral common carotid artery stenosis (BCAS)[3]
Dosage: 10 mg/kg
Administration: i.p., twice weekly, starting 3 days post-surgery for a total of 9 injections
Result: Reversed the reduction of doublecortin (DCX)-positive immature neurons in the hippocampal granular cell layer (GCL) and subgranular zone (SGZ).
Decreased the number of cleaved caspase-3/DCX double-positive apoptotic cells.
Promoted the survival and maturation of newborn neurons.
Attenuated the loss of cholinergic innervation in the hippocampal dentate gyrus.
Improved cognitive function.
Did not affect cerebral blood flow (CBF) in BCAS mice.
Clinical Trial
基因 ID

56963  [NCBI]

Accession

Q96B86-1
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.88 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Unasnemab on AHC2 biosensor, can bind RGMA Protein, Human (HEK293, His, HY-P76572) with an affinity constant of 1.418E-08 M as determined in BLI assay.
纯度 & 产品资料
参考文献

Unasnemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Unasnemab2379805-59-9MT-3921 rH116A3MT3921MT 3921Othersdiabetes-induced neurological impairmentsspinal cord injuryRGMaInhibitorinhibitorinhibit

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