2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. UNC10062

UNC10062 是一种多巴胺 D1 受体 (D1R) 正性变构调节剂。UNC10062 特异性结合于 D1R 的跨膜螺旋 (TM) 1 和 7 交界处的细胞外变构口袋。UNC10062 可增强多巴胺的效力以及 D1R 介导的环磷酸腺苷 (cAMP) 生成。UNC10062 可用于神经系统疾病的研究，如帕金森病。

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UNC10062

UNC10062 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

UNC10062 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC10062 is a dopamine D1 receptor (D1R) positive allosteric modulator. UNC10062 specifically binds to the extracellular allosteric pocket (upper pocket) at the interface of transmembrane helices (TM) 1 and 7 of D1R. UNC10062 can increase dopamine potency and D1R-mediated cAMP production. UNC10062 can be used for the research of neurological disease, such as Parkinson's disease[1].

IC50 & Target[1]

D1 Receptor

 

体外研究
(In Vitro)

UNC10062 (50 μM, 90 mins) 可提高多巴胺在稳定表达 D1R 的 CHO-K1 细胞中的效力，EC50 倍数变化为 3.9[1]。
UNC10062 (25-50 μM, 5 mins) 与 LY3154207 (HY-128770) 和 BMS-A1 联合使用时，可协同增强 HEK293 细胞中 D1R 介导的 cAMP 生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC10062 相关抗体:
分子量

401.48

Formula

C20H23N3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC10062 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC10062UNC 10062UNC-10062Dopamine ReceptorCHO-K1HEK293Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179241
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