2. PROTAC Immunology/Inflammation NF-κB MAPK/ERK Pathway
  3. Ligands for Target Protein for PROTAC IRAK NF-κB p38 MAPK
  4. UR241-2

UR241-2 是一种 IRAK4 抑制剂。UR241-2 可抑制 IL-1 诱导的 IRAK1/4 信号通路、NF-κβ 激活以及 p65 和 p38 的磷酸化。UR241-2 可选择性地抑制白血病干细胞的克隆形成能力。UR241-2 可作为 PROTAC 靶蛋白的配体，从而促进 IRAK4 PROTAC 降解剂的开发和设计。UR241-2 可用于急性髓系白血病的研究。

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UR241-2

UR241-2 Chemical Structure

CAS No. : 2597345-07-6

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规格 价格 是否有货 数量
1 mg ￥1200
3 - 5 周
5 mg ￥3060
3 - 5 周
10 mg ￥4950
3 - 5 周
25 mg 询价 3 - 5 周
50 mg 询价 3 - 5 周
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

UR241-2 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

查看所有亚型
IRAK1 IRAK4

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia[1].

IC50 & Target[1]

IRAK4

 

IRAK1

 

分子量

378.43

Formula

C20H22N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UR241-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UR241-22597345-07-6Ligands for Target Protein for PROTACIRAKNF-κBp38 MAPKTarget Protein-binding MoietyInterleukin-1 receptor associated kinaseIL-1R associated kinaseNuclear factor-κBNuclear factor-kappaBacute myeloid leukemiaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179095
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