2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis Caspase MDM-2/p53 Bcl-2 Family
  4. VEGFR-2-IN-70

VEGFR-2-IN-70 是一种强效的 VEGFR-2 抑制剂，IC50 为 18.04 nM。VEGFR-2-IN-70 对 A549 和 MCF-7 癌细胞表现出细胞毒性，IC50 分别为 0.43 μM 和 3.8 μM。VEGFR-2-IN-70 可诱导肺癌细胞 G1 期细胞周期阻滞和凋亡 (apoptosis)。VEGFR-2-IN-70 可用于癌症研究。

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VEGFR-2-IN-70

VEGFR-2-IN-70 Chemical Structure

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Customer Review

VEGFR-2-IN-70 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. VEGFR-2-IN-70 exhibits cytotoxicity against A549 and MCF-7 cancer cells with IC50 values of 0.43 μM and 3.8 μM, respectively. VEGFR-2-IN-70 induces G1 cell cycle arrest and apoptosis in lung cancer cells. VEGFR-2-IN-70 is useful in cancer research[1].

IC50 & Target[1]

VEGFR2

18.04 nM (IC50)

Bax

 

Caspase-8

 

Caspase-9

 

Caspase 3

 

体外研究
(In Vitro)

VEGFR-2-IN-70 (Compound 12g) (0.01-100 μM，48 小时) 可抑制 A549 和 MCF-7 癌细胞的生长，IC50 分别为 0.43 μM 和 3.86 μM[1]。

VEGFR-2-IN-70 (0.43 μM; 0-72 小时) 可抑制 A549 细胞的迁移[1]。

VEGFR-2-IN-70 (0.43 μM，48 小时) 可促进 A549 细胞凋亡，诱导促凋亡基因表达增加，并通过导致细胞周期停滞于 G1 期来抑制细胞生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-70 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0.43 μM
Incubation Time: 48 h
Result: Increased apoptosis, resulting in an overall apoptotic cell death rate of 23.12% (including 19.21% early apoptosis and 3.91% late apoptosis) .
Caused a slight increase in necrotic cell death (4.84%).

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0.43 μM
Incubation Time: 48 h
Result: Inhibited growth by causing cell cycle arrest at the G₁ phase, increased the percentage of cells in the G₁ phase to 76.53% and decreased the proportions of cells in the S phase and G₂/M phase to 19.36% and 4.11%, respectively.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 0.43 μM
Incubation Time: 48 h
Result: Induced an increased in the expression of pro-apoptotic genes, such as P53 (fold change = 10.8), Bax (fold change = 8.7), and Caspase-3 (fold change = 9.6), Caspase-8 (fold change = 1.2), and Caspase-9 (fold change = 8.7) .
Suppressed the expression of anti-apoptotic genes Bcl-2 with 0.13-fold change.
分子量

440.91

Formula

C20H17ClN6O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-70 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-70VEGFRApoptosisCaspaseMDM-2/p53Bcl-2 FamilyVascular endothelial growth factor receptorInhibitorA549 cellsMCF-7 cellsAnti-cancerinhibitorinhibit

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