2. PROTAC Anti-infection
  3. Ligands for E3 Ligase HIV
  4. Vpr (1-14)

Vpr (1-14) 是一种病毒蛋白 R (viral protein R)，同时是 HIV-1 的辅助蛋白。Vpr (1-14) 可与 Cul4A-DDB1-DCAF1 E3 连接酶复合物结合，还可作为 PROTAC 中的 E3 连接酶结合组分。Vpr (1-14) 可用于合成 PROTAC BRD4 Degrader-43 (HY-181164)。

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Custom Peptide Synthesis

Vpr (1-14)

Vpr (1-14) Chemical Structure

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Customer Review

Vpr (1-14) 相关抗体

Top Publications Citing Use of Products

查看 Ligands for E3 Ligase 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164)[1].

IC50 & Target[1]

Cul4A-DDB1-DCAF1

 

体外研究
(In Vitro)

Vpr (1-14) 相关抗体:

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 10, 30 μM (compounds 1, 4, 5, 11); 10, 50, 100 μM (compound 5); 1, 30 μM (compounds 7-9)
Incubation Time: unspecified time
Result: Showed weak dose-dependent BRD4 degradation at 10, 50, 100 μM, with significant degradation at 50 and 100 μM (compound 5); Did not exhibit significant BRD4 degradation (compounds 1, 4); Showed no (compounds 7, 8) or slight (compound 9) BRD4 degradation; Exhibited improved BRD4 degradation compared to compound 5 (compound 11)

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7 cells, J-Lat 10.6 cells, THP-1 NLuc#225 cells
Concentration: up to 50 μM (compounds 5, 11, 14)
Incubation Time: unspecified time
Result: Exhibited CC50 values >50 μM in J-Lat 10.6 and THP-1 NLuc#225 cells, and CC50 values of 52 μM (compound 5) and 45 μM (compound 11) in MCF-7 cells; Showed no significant cytotoxicity with CC50 >200 μM in MCF-7 cells, >50 μM in J-Lat 10.6 and THP-1 NLuc#225 cells (compound 14)
分子量

1610.70

Formula

C65H103N21O25S
Sequence

Met-Glu-Gln-Ala-Pro-Glu-Asp-Gln-Gly-Pro-Gln-Arg-Glu-Pro-NH2
Sequence Shortening

MEQAPEDQGPQREP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vpr (1-14) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vpr (1-14)Ligands for E3 LigaseHIVE3 ligase-recruiting MoietyHuman immunodeficiency virusubiquitin-proteasome systemMCF-7 cellsDCAF1THP-1 NLuc#225 cellsJ-Lat 10.6 cellsbreast cancerBRD4Cul4A-DDB1-DCAF1 E3 ligase complexHIV-1 infectionHIV-1 latencyInhibitorinhibitorinhibit

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产品名称：
Vpr (1-14)
目录号：
HY-P11640
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