VX-759 (Synonyms: VCH-759)

目录号: HY-119161 一键复制产品信息: Data Sheet 产品使用指南
FAQs
技术支持

VX-759 (VCH-759) 是一种口服有效的丙型肝炎病毒 NS5B RNA 依赖性 RNA 聚合酶 (HCV NS5B RNA-dependent RNA polymerase) 抑制剂。VX-759 有望用于慢性丙型肝炎的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

VX-759 Chemical Structure

CAS No. : 478025-29-5

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格		是否有货
50 mg		询价
100 mg		询价
250 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

VX-759 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性
纯度 & 产品资料
参考文献

生物活性

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	48 μM Compound: 2	Cytotoxicity against human HuH7 cells by WST-1 assay Cytotoxicity against human HuH7 cells by WST-1 assay	[PMID: 20584604]
Huh-7	CC₅₀	> 50000 nM Compound: 21	Cytotoxicity against human HuH7 cells by MTT assay Cytotoxicity against human HuH7 cells by MTT assay	[PMID: 19877603]
Huh-7	CC₅₀	>= 20 μM Compound: 9	Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay	[PMID: 24144213]
Huh-7	EC₅₀	0.23 μM Compound: 2	Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay	[PMID: 20584604]
Huh-7	EC₅₀	1400 nM Compound: 21	Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay	[PMID: 19877603]
Huh-7	EC₅₀	170 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2100 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	593 nM Compound: 9	Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	> 20 μM Compound: 9	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

分子量

385.52

Formula

C₂₂H₂₇NO₃S

CAS 号

478025-29-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Cooper C, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol. 2009 Jul;51(1):39-46. doi: 10.1016/j.jhep.2009.03.015. Epub 2009 Apr 23. [Content Brief]

VX-759 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VX-759478025-29-5VCH-759VX759VX 759VCH759VCH 759HCVHCV ProteaseHepatitis C virusHCV NS5B RNA-dependent RNA polymeraseInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VX-759 (Synonyms: VCH-759)

Customer Review

VX-759 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

VX-759 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

产品名称：			* Lot #：
* 客户姓名：			* Email：
电话：			* 部门：
* 公司或机构名称：
留言给我们：

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

VX-759 (Synonyms: VCH-759)

Customer Review

VX-759 相关抗体

VX-759 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

VX-759 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

Request for HNMR Report

Request for HNMR Report

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z