2. GPCR/G Protein
  3. Oxytocin Receptor
  4. WAY-267464

WAY-267464 是非肽催产素受体 (OTR) 激动剂。WAY-267464 通过抗利尿激素 1A 受体拮抗剂作用损害大鼠的社会认知。WAY-267464 可用于精神障碍的研究，如自闭症谱系障碍、精神分裂症和社交焦虑障碍。(OTR)

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WAY-267464

WAY-267464 Chemical Structure

CAS No. : 847375-16-0

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规格 价格 是否有货 数量
5 mg ￥1840
In-stock
10 mg ￥2960
In-stock
25 mg ￥5920
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of WAY-267464:

WAY-267464 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
420 nM
Compound: 1; WAY-267,464
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
[PMID: 26741855]
HEK293 EC50
> 10000 nM
Compound: 1; WAY-267,464
Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
[PMID: 26741855]
HEK293 IC50
613 nM
Compound: 1; WAY-267,464
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
[PMID: 26741855]
HEK293 IC50
> 10000 nM
Compound: 1; WAY-267,464
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
[PMID: 26741855]
体内研究
(In Vivo)

WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)[1]
Dosage: 1, 10, 30, and 100 mg/kg
Administration: Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result: Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.
Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
分子量

581.66

Formula

C32H35N7O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (85.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7192 mL 8.5961 mL 17.1922 mL
5 mM 0.3438 mL 1.7192 mL 3.4384 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

WAY-267464 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7192 mL 8.5961 mL 17.1922 mL 42.9804 mL
5 mM 0.3438 mL 1.7192 mL 3.4384 mL 8.5961 mL
10 mM 0.1719 mL 0.8596 mL 1.7192 mL 4.2980 mL
15 mM 0.1146 mL 0.5731 mL 1.1461 mL 2.8654 mL
20 mM 0.0860 mL 0.4298 mL 0.8596 mL 2.1490 mL
25 mM 0.0688 mL 0.3438 mL 0.6877 mL 1.7192 mL
30 mM 0.0573 mL 0.2865 mL 0.5731 mL 1.4327 mL
40 mM 0.0430 mL 0.2149 mL 0.4298 mL 1.0745 mL
50 mM 0.0344 mL 0.1719 mL 0.3438 mL 0.8596 mL
60 mM 0.0287 mL 0.1433 mL 0.2865 mL 0.7163 mL
80 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-267464847375-16-0WAY267464WAY 267464Oxytocin ReceptorOXTRoxytocin receptor (OTR)social recognition memoryvasopressin 1A receptorOxytocinVasopressinpsychiatric disordersautism spectrum disorderschizophreniasocial anxiety disorderInhibitorinhibitorinhibit

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