2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. WK2

WK2 是一种抗菌剂。WK2 可降低细菌 (Bacterial) 感染诱导的血清 TNF-α 生成。WK2 可在皮肤伤口感染模型中缩小伤口面积并促进组织修复。WK2 在肺炎模型中表现出显著的抗炎效果。WK2 可用于细菌感染的肺炎等感染疾病的研究。

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Custom Peptide Synthesis

WK2

WK2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

WK2 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WK2 is an antibacterial agent. WK2 reduces serum TNF-α production induced by Bacterial infection. WK2 reduces wound size and promotes tissue repair in a skin wound infection model. WK2 exerts significant anti-inflammatory effects in a pneumonia model. WK2 can be used for research on infectious diseases such as pneumonia caused by bacterial infection[1][2].

体外研究
(In Vitro)

WK2 以高亲和力结合 LPS，当 LPS 浓度超过 32 μg/mL时，会导致杀菌活性降低[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WK2 相关抗体:
体内研究
(In Vivo)

WK2 (5 mg/kg; i.p.; 6-36 h post-infection) 在小鼠 Klebsiella pneumoniae 肺炎模型中表现出显著的抗炎效果，可降低肺部细菌，并减轻感染的组织病理学体征[2]。
WK2 (2 mg/kg; topical; via 10 μL saline drops; 6-36 h post-infection) 在小鼠 MRSA 感染皮肤伤口模型中表现出抗菌活性，降低细菌载量，并促进伤口完全愈合及正常皮肤结构的再生[2]。
WK2 (15 mg/kg; i.p.; 30 min post-LPS injection) 在小鼠 LPS 诱导的全身炎症模型中表现出选择性抗炎活性，可降低血浆 TNF-α 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, intratracheal Klebsiella pneumoniae infection (50μL, 1×109 CFU/mL))[2]
Dosage: 5 mg/kg
Administration: i.p.; at 6, 12, 24, 30, and 36 h post-infection
Result: Reduced lung Klebsiella pneumoniae counts to 4.1 × 105 CFU/mg, compared to 2.67 × 106 CFU/mg in untreated infected mice.\nAlleviated inflammatory cell infiltration and promoted alveolar expansion, with less inflammation.
Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, dorsal wound methicillin-resistant Staphylococcus aureus infection (10 μL, 1 × 107 CFU/mL) )[2]
Dosage: 2 mg/kg
Administration: topical; via 10 μL saline drops; at 6, 12, 24, 30, and 36 h post-infection
Result: Exhibited significant antibacterial activity.
Demonstrated significant anti-MRSA activity, effectively preventing wound ulceration, gradually promoting wound healing, and causing the wound area to gradually decrease over time.
Improved the pathological changes in MRSA-infected mice, including wound thickening, inflammatory cell infiltration, and reduction of sebaceous glands and hair follicles.
Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, LPS (10 mg/kg,) i.p.)[2]
Dosage: 15 mg/kg
Administration: i.p.; 30 min post-LPS injection
Result: Reduced TNF-α levels induced by LPS.
分子量

1444.77

Formula

C76H105N19O10
Sequence

Gly-Trp-Trp-Lys-Lys-Trp-Trp-Lys-Lys-Ile-NH2
Sequence Shortening

GWWKKWWKKI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WK2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WK2WK 2WK-2BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRKlebsiella pneumoniaemethicillin-resistant Staphylococcus aureusLPSpneumoniaskin wound infectionBALB/c miceInhibitorinhibitorinhibit

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