WLBU2 

WLBU2 is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections^[1][2].

WLBU2 (5-90 μM, 24 小时 (非生物表面); 10-100 μM, 5 小时 (CFAECs)) 可防止非生物铜绿假单胞菌在非生物表面和人囊性纤维化气道上皮细胞 (CFAECs) 上的生物膜生长^[1]。
WLBU2 (50 μM, 5 小时) 在高盐 (100 mM Nacl) 和低 pH (6.5-7.0) 环境中仍保留了 CFAECs 中的生物膜预防活性^[1]。
WLBU2 (20 μM, 5 小时) 在 CFAECs 中与 Tobramycin (HY-B0441)、ciprofloxacin (HY-B0356)、Ceftazidime (HY-B0593) 和 Meropenem (HY-13678) 联合使用时表现出协同作用，但与 Colistin (HY-113678) 无协同作用^[1]。
WLBU2 对肺炎克雷伯菌的 MIC 值为 7.943 μM，鲍曼不动杆菌临床分离株的 MIC 值为 7.484 μM，且细菌分离株的 MBC 值与各自细菌的 MIC 值相同，表明其具有杀菌作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3400.11

C₁₅₁H₂₆₀N₆₆O₂₅

847061-43-2

Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg

RRWVRRVRRWVRRVVRVVRRWVRR

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lashua LP, et al. Engineered cationic antimicrobial peptide (eCAP) prevents Pseudomonas aeruginosa biofilm growth on airway epithelial cells. J Antimicrob Chemother. 2016 Aug;71(8):2200-7.  [Content Brief]

  [2]. Elsalem L, Khasawneh A, Al Sheboul S. WLBU2 Antimicrobial Peptide as a Potential Therapeutic for Treatment of Resistant Bacterial. Turk J Pharm Sci. 2022 Feb 28;19(1):110-116.