2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. WM-A1-3389

WM-A1-3389 是一种抗人 IGSF1 单克隆抗体和肿瘤生长抑制剂。WM-A1-3389 可特异性结合 IGSF1 的 C 端，促进 Granzyme B、IFN−γ 和 TNF−α 的分泌，并在异种或同种异体小鼠移植模型中抑制结肠癌或胆道癌的生长。WM-A1-3389 可用于结肠癌、胆道癌以及头颈癌的相关研究。

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WM-A1-3389

WM-A1-3389 Chemical Structure

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Customer Review

WM-A1-3389 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WM-A1-3389 is an anti-human IGSF1monoclonal antibody and tumor growth inhibitor. WM-A1-3389 specifically binds to the C-terminus of IGSF1, increases secretion of Granzyme B, IFN−γ, and TNF−α, and inhibits growth of colon cancer or biliary tract cancer in xenogeneic or allogeneic mouse implantation models. WM-A1-3389 can be used for the research of colon cancer, biliary tract cancer, and head and neck cancer[1].

反应种属

Human
体外研究
(In Vitro)

WM-A1-3389 antibody (24 h) 可在人结肠癌 HT29 细胞与 hPBMCs 的共培养体系中显著增加颗粒酶 B、IFN−γ 和 TNF−α 的分泌[1]。
WM-A1-3389 antibody (24 h) 可在人胆道癌 Choi-CK 细胞与 hPBMCs 的共培养体系中显著增加 Granzyme B、IFN−γ 和 TNF−α 的分泌[1]。
WM-A1-3389 antibody (24 h) 在人头颈部癌细胞 FaDu 细胞与 hPBMCs 的共培养体系中可显著促进 Granzyme B、IFN−γ 及 TNF−α 的分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WM-A1-3389 相关抗体:
体内研究
(In Vivo)

WM-A1-3389 antibody (30 mg/kg; i.p.; once every three days; four weeks) 在携带 HT29 结肠癌异种移植物的人源化小鼠中实现了 55.5% 的肿瘤生长抑制[1]。
WM-A1-3389 antibody (3-30 mg/kg; i.p.; once every three days; two weeks) 在接种 MC38 结肠癌同种异体移植物的 C57BL/6N 小鼠中实现了剂量依赖性的肿瘤生长抑制 (抑制率为 50.8%至 68.7%)[1]。
WM-A1-3389 antibody (3-50 mg/kg; i.p.; once every three days; two weeks) 在荷 CT26 结肠癌同种异体移植瘤的 C57BL/6N 小鼠中实现了剂量依赖性的肿瘤生长抑制 (抑制率为 44.9%至 66.0%)[1]。
WM-A1-3389 antibody (30 mg/kg; i.p.; once every three days; three weeks) 在携带 Choi-CK 胆道癌异种移植物的人源化小鼠中实现了 58.0 ± 4.3%的肿瘤生长抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: peripheral blood mononuclear cell humanized mice (6-week-old female; subcutaneous implantation of human colon cancer cell line HT29 cells)[1]
Dosage: 30 mg/kg
Administration: i.p.; once every three days; four weeks
Result: Achieved 55.5% tumor growth inhibition relative to the negative control group, with a statistically.
Animal Model: C57BL/6N mice (5-week-old female; subcutaneous implantation of mouse colon cancer cell line MC38 cells)[1]
Dosage: 3 mg/kg; 10 mg/kg; 30 mg/kg
Administration: i.p.; once every three days; two weeks
Result: Achieved 50.8% tumor growth inhibition relative to the negative control group at 3 mg/kg.
Achieved 58.2% tumor growth inhibition relative to the negative control group at 10 mg/kg.
Achieved 68.7% tumor growth inhibition relative to the negative control group at 30 mg/kg.
Showed a dose-dependent increase in tumor growth inhibition.
Animal Model: C57BL/6N mice (5-week-old female; subcutaneous implantation of mouse colon cancer cell line CT26 cells)[1]
Dosage: 3 mg/kg; 10 mg/kg; 50 mg/kg
Administration: i.p.; once every three days; two weeks
Result: Achieved 44.9% tumor growth inhibition relative to the negative control group at 3 mg/kg.
Achieved 57.0% tumor growth inhibition relative to the negative control group at 10 mg/kg.
Achieved 66.0% tumor growth inhibition relative to the negative control group at 50 mg/kg.
Showed a dose-dependent increase in tumor growth inhibition.
Animal Model: peripheral blood mononuclear cell humanized mice (6-week-old female; subcutaneous implantation of human biliary tract cancer cell line Choi-CK cells)[1]
Dosage: 30 mg/kg
Administration: i.p.; once every three days; three weeks
Result: Achieved 58.0% tumor growth inhibition relative to the negative control group, with a statistically.
基因 ID

3547  [NCBI]

Accession

Q8N6C5
靶点

IGSF1
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WM-A1-3389 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WM-A1-3389Transmembrane GlycoproteinHT29 cellsIGSF1Granzyme Bhead and neck cancerhPBMCsTNF-αcolon cancerbiliary tract cancerChoi-CK cellsIFN-γInhibitorinhibitorinhibit

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目录号：
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