2. PI3K/Akt/mTOR Apoptosis MAPK/ERK Pathway Stem Cell/Wnt
  3. PI3K Apoptosis PDK-1 MEK Akt ERK
  4. X-370

X-370 是一种 PI3Kδ 抑制剂 (IC50 = 7 nM)。X-370 抑制白血病细胞的存活率，诱导 G1 停止和细胞凋亡 (apoptosis)。X-370 通过阻断 PDK1 与 MEK1/2 的结合和对 MEK1/2 的磷酸化，从而废除了 Akt 和 Erk1/2 信号通路。X-370 可用于 B 细胞急性淋巴细胞白血病 (B-ALL) 的研究。

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X-370

X-370 Chemical Structure

CAS No. : 1280725-80-5

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X-370 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 MEK 亚型特异性产品:

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL)[1].

分子量

551.59

Formula

C27H31F2N9O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

X-370 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

X-3701280725-80-5X370X 370PI3KApoptosisPDK-1MEKAktERKPhosphoinositide 3-kinase3-Phosphoinositide-dependent protein kinase 1Mitogen-activated protein kinase kinaseMAPKKMAP2KPKBProtein kinase BExtracellular signal regulated kinasesPI3Kδ inhibitorleukemia cellsapoptosis,B-cell acute lymphoblastic leukemiaInhibitorinhibitorinhibit

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