2. GPCR/G Protein
  3. Vasopressin Receptor
  4. XYDC2050

XYDC2050 (Compound 29) 是一种选择性的血管加压素 V2 受体 (V2R) 拮抗剂，其 IC50 值为 27 nM，Ki 值为 2.8 nM。XYDC2050 对 V1R 的 Ki 值为 420.7 nM， SI 为 162 倍。XYDC2050 能抑制 Vasopressin (HY-B1811) 诱导的细胞内环磷酸腺苷 (cAMP) 积累，其 IC50 值为 12 nM。XYDC2050 能够抑制肾囊肿的生长，降低肾重与体重的比值，减小囊肿面积和囊性指数。XYDC2050 可用于常染色体显性多囊肾病 (ADPKD) 的研究。

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XYDC2050

XYDC2050 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

XYDC2050 相关抗体

Top Publications Citing Use of Products

查看 Vasopressin Receptor 亚型特异性产品:

查看所有亚型
V1a Receptor  V1b Receptor  V2 Receptor 

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC50 of 27 nM and a Ki of 2.8 nM. XYDC2050 shows a Ki of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC50 of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC50 & Target[1]

V2 Receptor 

27 nM (IC50)

V2 Receptor 

2.8 nM (Ki)

分子量

532.56

Formula

C33H25FN2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XYDC2050 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XYDC2050XYDC 2050XYDC-2050Vasopressin ReceptorInhibitorinhibitorinhibit

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产品名称：
XYDC2050
目录号：
HY-180142
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