2. Apoptosis
  3. c-Myc Apoptosis
  4. Y502-3888

Y502-3888 是一种 c-Myc 抑制剂。Y502-3888 可结合 c-Myc G4 结构，抑制 c-Myc 转录，并在 mRNA 和蛋白水平下调 c-Myc 的表达。Y502-3888 抑制骨髓瘤细胞的细胞活力，并诱导了细胞凋亡 (apoptosis)。Y502-3888 可用于多发性骨髓瘤的研究。

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Y502-3888

Y502-3888 Chemical Structure

CAS No. : 828292-11-1

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Y502-3888 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Y502-3888 is a c-Myc inhibitor. Y502-3888 binds to the c-Myc G4 structure, inhibits c-Myc transcription, and downregulates c-Myc expression at both mRNA and protein levels. Y502-3888 inhibits the viability of myeloma cells and induces cell apoptosis. Y502-3888 can be used for the research of multiple myeloma[1].

体外研究
(In Vitro)

Y502-3888 (48 h) 可强效且选择性地抑制人多发性骨髓瘤 RPMI 8226 细胞与 U266 细胞的活力，其 IC50 值分别为 12.67 μM 和 7.03 μM，而对非恶性 HEK293T 细胞的毒性极低[1]。
Y502-3888 (5-20 μM; 48 h) 可剂量依赖性地诱导人多发性骨髓瘤 U266 细胞发生凋亡[1]。
Y502-3888 (5-20 μM; 48 h) 可在人多发性骨髓瘤 U266 细胞中呈剂量依赖性地下调 c-Myc 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Y502-3888 相关抗体:

Apoptosis Analysis[1]

Cell Line: Human multiple myeloma U266 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Induced dose-dependent increases in apoptotic cell populations.\nResulted in 8.68% early apoptotic and 15.4% late apoptotic cells at 5 μM.\n
Resulted in 16.2% early apoptotic and 26.2% late apoptotic cells at 10 μM.
Resulted in 24.9% early apoptotic and 57.0% late apoptotic cells at 20 μM.

Western Blot Analysis[1]

Cell Line: Human multiple myeloma U266 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Reduced c-Myc protein levels in a dose-dependent manner.\n
Caused statistically significant reductions in c-Myc protein levels at 10 μM and 20 μM relative to control cells.\n
Markedly decreased c-Myc protein levels at 20 μM.

Real Time qPCR[1]

Cell Line: Human multiple myeloma U266 cells, CA46 Burkitt's lymphoma cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Reduced c-Myc mRNA levels in U266 cells in a dose-dependent manner, with expression reduced to ~50% of control at 20 μM.\n
Dose-dependently suppressed Exon 1 c-Myc mRNA levels in CA46 cells, with minimal effect on Exon 2 levels.
分子量

410.45

Formula

C19H18N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Y502-3888 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y502-3888828292-11-1c-MycApoptosisMycc-Myc transcriptionmultiple myelomac-Myc G-quadruplex DNA structurec-Myc proteinHEK293T cellsU266 cellsc-Myc mRNAtelomeric G-quadruplexCA46 Burkitt's lymphoma cellsRPMI 8226 cellsInhibitorinhibitorinhibit

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