2. Immunology/Inflammation
  3. IFNAR
  4. YE6144 free base

YE6144 free base 是一种选择性原型干扰素调节因子 5 (IRF5) 抑制剂。YE6144 free base 在系统性红斑狼疮 (SLE) 小鼠模型中能够抑制疾病进程，并且在维持缓解方面尤为有效。YE6144 free base 可用于 SLE 研究。

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YE6144 free base

YE6144 free base Chemical Structure

CAS No. : 3065657-01-1

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YE6144 free base 的其他形式现货产品:

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YE6144 free base 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research[1].

IC50 & Target[1]

IRF5

 

体外研究
(In Vitro)

YE6144 (1 或 3 μM；30 分钟) free base 可抑制人外周血单核细胞 (PBMC) 和小鼠脾细胞中 IRF5 的磷酸化[1]。
YE6144 (0-10 μM；30 分钟) free base 可抑制人健康对照组 (HC) PBMC 中 I 型干扰素 (IFN) 的产生，其 IC50 值约为 0.09 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YE6144 free base 相关抗体:

Western Blot Analysis[1]

Cell Line: Human HC PBMCs and mouse WT splenocytes
Concentration: 1 μM (PBMCs) and 3 μM (splenocytes)
Incubation Time: 30 min
Result: Inhibited the phosphorylation of IRF5.

RT-PCR[1]

Cell Line: Mouse WT splenocytes
Concentration: 3 μM
Incubation Time: 30 min
Result: Induction of type I IFN genes, Ifnb1 and Ifna stimulated by TLR7 ligands or TLR9 ligands was remarkably weakened.
体内研究
(In Vivo)

YE6144 (40.0 mg/kg；皮下注射；一次) free base 可抑制小鼠系统性红斑狼疮的进展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NZB/W F1 mouse model of systemic lupus erythematosus (SLE)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; once
Result: Suppressed the exacerbation of autoantibody production.
Splenomegaly and renal dysfunction were also suppressed by the treatment after disease onset.
分子量

411.48

Formula

C21H26FN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YE6144 free base 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YE61443065657-01-1YE 6144YE-6144IFNARInterferon-α/β receptorInterferon-alpha/beta receptorhuman PBMCsmouse splenocytesNZB/W F1 mousesystemic lupus erythematosusInhibitorinhibitorinhibit

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产品名称：
YE6144 free base
目录号：
HY-150095A
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