2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. YJC-10592

YJC-10592 是一种口服活性的 CCR-2 拮抗剂。YJC-10592 与 HAS 结合。YJC-10592 可用于哮喘和特发性皮炎的研究。

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YJC-10592

YJC-10592 Chemical Structure

CAS No. : 1226894-87-6

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YJC-10592 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YJC-10592 is an orally active CCR-2 antagonist. YJC-10592 binds to HAS. YJC-10592 can be used in the research of asthma and idiopathic dermatitis[1].

IC50 & Target[1]

CCR2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.0017 μM
Compound: 47
Antagonist activity at human CCR2B receptor expressed in HEK293 cells assessed as inhibition of MCP1-induced increase in intracellular calcium level
Antagonist activity at human CCR2B receptor expressed in HEK293 cells assessed as inhibition of MCP1-induced increase in intracellular calcium level
[PMID: 20223662]
HEK293-EBNA IC50
1.12 μM
Compound: 47
Displacement of [125I]MCP1 from human CCR2B receptor expressed in HEK293-EBNA cells
Displacement of [125I]MCP1 from human CCR2B receptor expressed in HEK293-EBNA cells
[PMID: 20223662]
THP-1 IC50
0.023 μM
Compound: 47
Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of MCP1-induced chemotaxis after 1 hr by crystal violet staining
Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of MCP1-induced chemotaxis after 1 hr by crystal violet staining
[PMID: 20223662]
分子量

566.01

Formula

C27H31ClF3N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YJC-10592 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YJC-105921226894-87-6YJC10592YJC 10592CCRCC chemokine receptorasthmaidiopathic dermatitisInhibitorinhibitorinhibit

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产品名称：
YJC-10592
目录号：
HY-136768
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