2. PROTAC Apoptosis MAPK/ERK Pathway
  3. PROTACs RIP kinase Mixed Lineage Kinase
  4. ZBP1 Covalent PROTAC-1

ZBP1 Covalent PROTAC-1 是一种共价 Z-DNA 结合蛋白 1 ZBP1 PROTAC 降解剂，其 DC50 为 25.69 nM。ZBP1 Covalent PROTAC-1 整合了招募 VHL E3 泛素连接酶的配体和能特异性结合 ZBP1 的 Zα 结构域的 DNA 适配体 (Aptamer Z3)，其与 ZBP1 具有很高的亲和力 (KD = 2.71 nM)。ZBP1 Covalent PROTAC-1 降解 ZBP1 后，其下游信号分子 RIPK3 和 MLKL 的磷酸化水平显著降低。ZBP1 Covalent PROTAC-1 采用纳米脂质体包裹后通过气管给药显著改善了甲型流感病毒 (IAV) 感染的小鼠的生存率。

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ZBP1 Covalent PROTAC-1

ZBP1 Covalent PROTAC-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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ZBP1 Covalent PROTAC-1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 RIP kinase 亚型特异性产品:

查看所有亚型
RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC50 being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (KD = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea[1].

分子量

24590.00

性状

固体

颜色

White to pink

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

ZBP1 Covalent PROTAC-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZBP1 Covalent PROTAC-1PROTACsRIP kinaseMixed Lineage KinaseReceptor-interacting protein kinasesRIPKMLKsCovalent PROTACsTargeted DegradationAnti-Inflammatory TreatmentViral InfectionsDNA AptamerNASANecroptosisInhibitorinhibitorinhibit

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产品名称：
ZBP1 Covalent PROTAC-1
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HY-177119
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