2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Androgen Receptor Apoptosis
  4. ZC9

ZC9 是一种新型的雄激素受体 (AR) 降解剂。ZC9 直接与 AR 结合，抑制 Dihydrotestosterone 诱导的 AR 核转位。ZC9 通过泛素-蛋白酶体系统促进 AR 降解，并抑制 AR 的转录活性。ZC9 显著降低其他 AR 下游基因的 mRNA 水平，包括 PSA、TMPRSS2 和 PMEPA1。ZC9 促进凋亡 (Apoptosis)。ZC9 对前列腺癌具有抗癌活性。

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ZC9

ZC9 Chemical Structure

CAS No. : 2757513-79-2

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ZC9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZC9 is a novel androgen receptor (AR) degrader. ZC9 directly binds to AR and inhibits Dihydrotestosterone-induced nuclear translocation of AR. ZC9 promotes AR degradation via the ubiquitin-proteasome system and suppresses AR transcriptional activity. ZC9 significantly decreases the mRNA levels of other AR downstream genes, including PSA, TMPRSS2, and PMEPA1. ZC9 promotes Apoptosis. ZC9 exhibits anticancer activity against prostate cancer[1].

分子量

461.56

Formula

C24H19N3O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZC9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZC92757513-79-2ZC 9ZC-9Androgen ReceptorApoptosisProstate CanceranticancerCRPCLNCaPPC-322Rv1C4-2Inhibitorinhibitorinhibit

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目录号：
HY-179123
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