α-Amyrin (Synonyms: α-香树脂醇)

目录号: HY-N8423 纯度: 99.73%: Data Sheet SDS COA 产品使用指南
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α-Amyrin 是一种具有口服活性的五环三萜类化合物。α-Amyrin 可激活 ERK 和 GSK-3β 信号通路。α-Amyrin 能够抑制癌细胞增殖并诱导细胞凋亡 (apoptosis)。α-Amyrin 具有抗菌和抗炎活性。α-Amyrin 可以降低血糖水平。α-Amyrin 可用于癌症、感染、炎症、代谢性疾病和神经系统疾病的研究，如乳腺癌、口腔链球菌 (Streptococcus oralis) 感染、皮肤炎症和糖尿病。

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α-Amyrin Chemical Structure

CAS No. : 638-95-9

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5 mg	￥995	In-stock
10 mg	￥1750	In-stock
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Customer Review

Other Forms of α-Amyrin:

α-Amyrin (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Trop Med Infect Dis. 2023 May 3;8(5):263. [Abstract]

α-Amyrin 相关产品

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ERK ERK1 ERK2 ERK5 ERK8

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GSK-3 GSK-3α GSK-3β

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COX COX-1 COX-2 COX-3

生物活性
纯度 & 产品资料
参考文献

生物活性

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes^[1]^[2]^[3]^[4]^[5]^[6]^[7].

IC₅₀ & Target^[1]

GSK-3β

Caspase 3

COX-2

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	GI₅₀	10.54 μM Compound: 58	Cytotoxicity against human A549 cells after 48 hrs by WST8 assay Cytotoxicity against human A549 cells after 48 hrs by WST8 assay	[PMID: 20371180]
B16	ED₅₀	> 50 μM Compound: 19	Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days	[PMID: 12027734]
B16	IC₅₀	50 μM Compound: 19	Growth inhibition of mouse B16 2F2 cells after 3 days Growth inhibition of mouse B16 2F2 cells after 3 days	[PMID: 12027734]
CHO	EC₅₀	> 10 μM Compound: Alpha-amyrin	Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay	[PMID: 19911773]
COS-1	EC₅₀	0 μM Compound: Alpha-amyrin	Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay	[PMID: 19911773]
HepG2	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
HepG2	IC₅₀	220 μM Compound: 8	Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay	[PMID: 15730243]
J774	IC₅₀	128.5 μM Compound: 1	Cytotoxicity against mouse J774 cells by alamar blue assay Cytotoxicity against mouse J774 cells by alamar blue assay	[PMID: 17637068]
KB	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
Lu1	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
MCF7	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
PANC-1	GI₅₀	12.8 μM Compound: 58	Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay	[PMID: 20371180]
PC-3	GI₅₀	7.66 μM Compound: 58	Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay	[PMID: 20371180]
SH-SY5Y	EC₅₀	> 50 μM Compound: 37	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay	[PMID: 27420919]
SH-SY5Y	EC₅₀	13.3 μM Compound: 37	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay	[PMID: 27420919]
WI-38	IC₅₀	12.7 μM Compound: 8	Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay	[PMID: 15730243]
WI-38 VA13	IC₅₀	> 235 μM Compound: 8	Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay	[PMID: 15730243]

体外研究
(In Vitro)

α-Amyrin (10 μM, 24 h) 可诱导 C2C12 成肌细胞中 AMPK 和 PPARδ/γ 介导的 GLUT4 易位^[1]。
α-Amyrin (acetate) (2.5-10 μg/mL, 0-72 h) 可抑制 MDA-MB-231 细胞的增殖和集落形成^[6]。
α-Amyrin (acetate) (5-10 μg/mL, 24 h) 可诱导 MDA-MB-231 细胞凋亡并增加 caspase-3 活性^[6]。
α-Amyrin (acetate) (10 μg/mL, 24 h) 可促进 MDA-MB-231 细胞中多聚腺苷二磷酸核糖聚合酶的裂解，增加 E-钙粘蛋白，并抑制波形蛋白和磷酸化细胞外信号调节的激活^[6]。
α-Amyrin (10-1000 μg/mL, 24 h) 会降低唾液链球菌 (Streptococcus salivarius)、血链球菌 (Streptococcus sanguinis) 和口腔链球菌 (Streptococcus oralis) 的存活率^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	C2C12 cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Increased the mRNA and protein expression of PPARs, GLUT4 and FATP.

Apoptosis Analysis^[2]

Cell Line:	MDA-MB-231 cells
Concentration:	5 and 10 μg/mL
Incubation Time:	24 h
Result:	Increased apoptotic cells. Increased caspase-3 activity.

体内研究
(In Vivo)

α-Amyrin (50-200 mg/kg，口服，每天一次，持续 42 天) 可降低高果糖饮食诱导的代谢综合征大鼠的存活率^[2]。
α-Amyrin (2-4 mg/kg，口服) 通过激活 ERK 和 GSK-3β 信号通路，改善小鼠因胆碱能神经传递低下引起的认知功能障碍^[3]。
α-Amyrin (acetate) (50 mg/kg，口服，每日一次，持续 1-10 天) 可降低糖尿病大鼠的血糖水平^[4]。
α-Amyrin (0.1-1.0 mg/ear，局部涂抹) 可抑制12-氧-十四烷酰佛波醇-13-乙酸酯 (TPA) 诱导的小鼠皮肤炎症^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fructose diet (HFD)-induced metabolic syndrome in rats^[2]
Dosage:	50, 100 and 200 mg/kg
Administration:	Orally administration
Result:	Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides. Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.

Animal Model:	Scopolamine-Induced Memory Impairment Mice^[3]
Dosage:	2 and 4 mg/kg
Administration:	Orally administration
Result:	Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β).

Animal Model:	12-O-tetradecanoylphorbol-acetate (TPA)-induced skin inflammation of mice^[5]
Dosage:	0.1, 0.3 and 1.0 mg/ear, topical application
Administration:	Topically application
Result:	Inhibited skin inflammation. Reduced COX-2 levels and activation of NF-κB and MAPKs.

分子量

426.72

Formula

C₃₀H₅₀O

CAS 号

638-95-9

性状

固体

颜色

White to off-white

中文名称

α-香树脂醇

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 5 mg/mL (11.72 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Methanol 中的溶解度 : 1 mg/mL (2.34 mM; 超声助溶 (<60°C))

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3435 mL	11.7173 mL	23.4346 mL
5 mM	0.4687 mL	2.3435 mL	4.6869 mL
10 mM	0.2343 mL	1.1717 mL	2.3435 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.94%

选择批次：

Data Sheet (635 KB) SDS (392 KB)

COA (290 KB) HNMR (294 KB) RP-HPLC (133 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942. [Content Brief]

[2]. Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32. [Content Brief]

[3]. Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13. [Content Brief]

[4]. Singh AB, et al. Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice. Nat Prod Res. 2009;23(9):876-82. [Content Brief]

[5]. Medeiros R, et al. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol. 2007 Mar 22;559(2-3):227-35. [Content Brief]

[6]. Kevine Kamga Silihe, Purification of α-amyrin-acetate and phenylpropanoïd compounds from Ficus umbellata Vahl (Moraceae) stem bark and evaluation of their anti-breast cancer potential, South African Journal of Botany, 177 (2025) 445-456.

[7]. Díaz-Ruiz G, et al. Growth inhibition of Streptococcus from the oral cavity by α-amyrin esters. Molecules. 2012 Oct 25;17(11):12603-11. [Content Brief]

α-Amyrin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

Methanol / DMSO	1 mM	2.3435 mL	11.7173 mL	23.4346 mL	58.5864 mL
DMSO	5 mM	0.4687 mL	2.3435 mL	4.6869 mL	11.7173 mL
DMSO	10 mM	0.2343 mL	1.1717 mL	2.3435 mL	5.8586 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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α-Amyrin (Synonyms: α-香树脂醇)

Customer Review

Other Forms of α-Amyrin:

MCE 顾客使用本产品发表的 1 篇科研文献