顺式四氯二氨铂(IV)
顺式四氯二氨铂(IV)结构式
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常用名 | 顺式四氯二氨铂(IV) | 英文名 | Platinum,diamminetetrachloro-, (OC-6-22)- |
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| CAS号 | 16893-05-3 | 分子量 | 368.93500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | Cl4H4N2Pt | 熔点 | >300ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS05, GHS06, GHS08 |
信号词 | Danger |
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Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.
Cancer Res. 44(5) , 2043-51, (1984) Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV)] are known to possess antitumor activity, whereas... |
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Toxicity, mutagenicity and induction of recA protein in Escherichia coli treated with cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV).
Chem. Biol. Interact. 60(2) , 207-15, (1986) After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magnitude greater than DDP. However, at identical intracellular ... |
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Detection of DNA strand breaks in Escherichia coli treated with platinum(IV) antitumor compounds.
Chem. Biol. Interact. 74(3) , 343-52, (1990) DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which was detected by a rapid bacterial assay. In addition, the ... |