Model studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinones

KS Gates, RB Silverman

文献索引：Gates, Kent S.; Silverman, Richard B. Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8891 - 8895

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被引用次数: 20

摘要

Abstract: 3-[4-[(3-Chlorophenyl) methoxy] phenyl]-5-[(methylamino) methyl]-2-oxazolidinone (MD 780236) has been reported to be an irreversible inactivator of monoamine oxidase (MAO), but the mechanism of inactivation is not known. A mechanism is now proposed that involves one-electron transfer to give the corresponding amine radical cation, removal of an a-proton, and decomposition of the oxazolidinone ring with loss of C02 to another radical ...