Resolution of Racemic N??Benzyl α??Amino Acids by Liquid??Liquid Extraction: A Practical Method Using a Lipophilic Chiral Cobalt (III) Salen Complex and Mechanistic …

…, M Krupicka, I Tvaroska, C Gennari

文献索引：Dzygiel, Pawel; Reeve, Toby B.; Piarulli, Umberto; Krupicka, Martin; Tvaroska, Igor; Gennari, Cesare European Journal of Organic Chemistry, 2008 , # 7 p. 1253 - 1264

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被引用次数: 21

摘要

Abstract The efficient resolution of racemic N-benzyl α-amino acids (N-Bn-AA) has been achieved by a liquid-liquid extraction process using the lipophilic chiral salen–cobalt (III) complex [Co III (3)(OAc)]. As a result of the resolution by extraction, one enantiomer (S) of the N-benzyl α-amino acid predominated in the aqueous phase, while the other enantiomer (R) was driven into the organic phase by complexation to cobalt. The complexed amino ...