Studies on the stability of trimelamol, a carbinolamine??containing antitumor drug

…, R Godfrey, R Saunders, DE Thurston

文献索引：Jackson; Crabb; Gibson; Godfrey; Saunders; Thurston Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 3 p. 245 - 251

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被引用次数: 14

摘要

Abstract The stability of trimelamol N 2, N 4, N 6-trimethylol-N 2, N 4, N 6- (trimethylmelamine) a synthetic carbinolamine-containing antitumor drug, has been studied. Two major degradation pathways have been characterized and a unified mechanism proposed to rationalize the chemistry involved. One degradation pathway involves the consecutive loss of hydroxymethylene units by elimination of formaldehyde until the ...