Efficient synthesis of polysubstituted acylguanidines and guanylureas

AR Katritzky, BV Rogovoy, X Cai…

文献索引：Augustin, M.; Richter, M.; Salas, S. Journal fuer Praktische Chemie (Leipzig), 1980 , vol. 322, # 1 p. 55 - 68

被引用次数: 20

摘要

... Volume: Page: ... Journal ... All the acyl-substituted (benzotriazole-1-yl)carboximidamides gave the desired guanidines 7a−d,k−o in good to excellent yields in reactions with primary and secondary alkylamines, anilines, and α-amino esters. ...

~60%

~51%

~63%

~92%

~43%

~47%

Combining hit identification strategies: fragment-based and ...

[Brough, Paul A.; Barril, Xavier; Borgognoni, Jenifer; Chene, Patrick; Davies, Nicholas G. M.; Davis, Ben; Drysdale, Martin J.; Dymock, Brian; Eccles, Suzanne A.; Garcia-Echeverria, Carlos; Fromont, Christophe; Hayes, Angela; Hubbard, Roderick E.; Jordan, Allan M.; Jensen, Michael Rugaard; Massey, Andrew; Merrett, Angela; Padfield, Antony; Parsons, Rachel; Radimerski, Thomas; Raynaud, Florence I.; Robertson, Alan; Roughley, Stephen D.; Schoepfer, Joseph; Simmonite, Heather; Sharp, Swee Y.; Surgenor, Allan; Valenti, Melanie; Walls, Steven; Webb, Paul; Wood, Mike; Workman, Paul; Wright, Lisa Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4794 - 4809]