A “tag-and-modify” approach to site-selective protein modification

JM Chalker, GJL Bernardes…

文献索引：Lin, Yuya A.; Chalker, Justin M.; Floyd, Nicola; Bernardes, Goncalo J. L.; Davis, Benjamin G. Journal of the American Chemical Society, 2008 , vol. 130, # 30 p. 9642 - 9643

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被引用次数: 160

摘要

Covalent modification can expand a protein's functional capacity. Fluorescent or radioactive labeling, for instance, allows imaging of a protein in real time. Labeling with an affinity probe enables isolation of target proteins and other interacting molecules. At the other end of this functional spectrum, protein structures can be naturally altered by enzymatic action. Protein– protein interactions, genetic regulation, and a range of cellular processes are under the ...