'One-pot'synthesis of 4-substituted 1, 5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr …

…, WB Huang, JJ Zhai, HW Liu, Q Cai, LX Xu, W Wang…

文献索引：Jiang, Jian-An; Huang, Wei-Bin; Zhai, Jiao-Jiao; Liu, Hong-Wei; Cai, Qi; Xu, Liu-Xin; Wang, Wei; Ji, Ya-Fei Tetrahedron, 2013 , vol. 69, # 2 p. 627 - 635

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被引用次数: 14

摘要

A concise 'one-pot'synthesis of a variety of 4-substituted 1, 5-diaryl-1H-pyrazole-3- carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2, 4-diketoesters. Furthermore, extensive studies lead to a 'one-pot'process by combination of the Claisen ...