Convenient preparation of polyfunctional aryl magnesium reagents by a direct magnesium insertion in the presence of LiCl

…, P Appukkuttan, A Gavryushin, M Helm…

文献索引：Piller, Fabian M.; Appukkuttan, Prasad; Gavryushin, Andrei; Helm, Matthew; Knochel, Paul Angewandte Chemie - International Edition, 2008 , vol. 47, # 36 p. 6802 - 6806

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被引用次数: 177

摘要

The preparation of complex polyfunctional organometallic reagents is of pivotal interest in organic synthesis.[1] Recently, functionalized organomagnesium reagents have become accessible through a halogen/magnesium exchange [2] or a directed metalation.[3] During these studies it became apparent that aryl magnesium halides are compatible with important functional groups, such as cyano, nitro, ester, or even keto groups.[4] This observation ...