Mn-mediated coupling of alkyl iodides and ketimines: A radical addition route to α, α-disubstituted α-aminoesters

GK Friestad, A Ji

文献索引：Friestad, Gregory K.; Ji, An Organic Letters, 2008 , vol. 10, # 11 p. 2311 - 2313

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被引用次数: 33

摘要

We have addressed this problem by developing Mn-mediated coupling of alkyl iodides with N-acylhydrazones,(2) exploiting conditions of notable versatility with respect to both coupling components.(3) Until now, these Mn-mediated coupling reactions have been limited to aldehyde-derived imino acceptors. However, additions to ketone-derived imino compounds(4) are of particular interest as they could provide a diverse range of tert-alkyl ...