New method of fluorination using potassium fluoride in ionic liquid: significantly enhanced reactivity of fluoride and improved selectivity

DW Kim, CE Song, DY Chi

文献索引：Kim, Dong Wook; Song, Choong Eui; Chi, Dae Yoon Journal of the American Chemical Society, 2002 , vol. 124, # 35 p. 10278 - 10279

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被引用次数: 204

摘要

We have found the new nucleophilic fluorination reaction of some halo-and mesylalkanes to the corresponding fluoroalkanes with KF in the presence of [bmim][BF4] under various reaction conditions. 2-(3-Methanesulfonyloxypropoxy) naphthalene (1) was used as a model compound to optimize this fluorination reaction. Whereas the fluorination of the mesylate 1 with KF in an organic solvent such as CH3CN at 100° C occurred hardly even after 24 h, ...