Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes

W Lin, I Sapountzis, P Knochel

文献索引：Lin, Wenwei; Sapountzis, Ioannis; Knochel, Paul Angewandte Chemie - International Edition, 2005 , vol. 44, # 27 p. 4258 - 4261

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被引用次数: 60

摘要

The functionalization of arenes is an important synthetic task.[1] A potential approach is the addition reaction of nucleophiles to intermediate arynes.[2] The addition of heteroatom– metal bonds (NuÀMet; Nu= OR, NR2, SR, PR2) to alkynes is usually a difficult process due to the high energy of the NuÀMet bond and to the high nucleophilicity of the resulting CÀMet bond of the adduct, which is prone to undergo polymerization and other side reactions.[3] ...