Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes

F Besselièvre, S Piguel, F Mahuteau-Betzer…

文献索引：Besselievre, Francois; Piguel, Sandrine; Mahuteau-Betzer, Florence; Grierson, David S. Organic Letters, 2008 , vol. 10, # 18 p. 4029 - 4032

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被引用次数: 110

摘要

A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio-and stereoselective and tolerates a variety of functional groups. A wide range of 2-E-vinyl-substituted oxazoles were obtained in high yields including the highly fluorescent alkaloid annuloline.