Rhodium-HMPT-catalyzed direct ortho arylation of phenols with aryl bromides

S Oi, S Watanabe, S Fukita, Y Inoue

文献索引：Oi, Shuichi; Watanabe, Shun-Ichiro; Fukita, Susumu; Inoue, Yoshio Tetrahedron Letters, 2003 , vol. 44, # 48 p. 8665 - 8668

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被引用次数: 104

摘要

Direct ortho arylation of phenols with aryl bromides catalyzed by a rhodium complex and hexamethylphosphorous triamide (HMPT) have been developed. A plausible reaction mechanism involving in situ generation of arylphosphites from phenols and HMPT, phosphorus-directed ortho metalation, and transesterification of the arylated arylphosphites with the substrate phenols is proposed.