Continuous-flow hydration–condensation reaction: Synthesis of α, β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid …

M Rueping, T Bootwicha, H Baars…

文献索引：Rueping, Magnus; Bootwicha, Teerawut; Baars, Hannah; Sugiono, Erli Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 1680 - 1687

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被引用次数: 15

摘要

Abstract A simple, practical and efficient continuous-flow hydration–condensation protocol was developed for the synthesis of α, β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.