Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer

T Suzuki, N Fukazawa, K San-nohe…

文献索引：Suzuki, Tsuneji; Fukazawa, Nobuyuki; San-nohe, Kunio; Sato, Wakao; Yano, Osamu; Tsuruo, Takashi Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2047 - 2052

全文：HTML全文

被引用次数: 101

摘要

The effect of 24 newly synthesized quinoline derivatives on tumor cell multidrug resistance (MDR) was examined in vitro. At low concentrations, these compounds enhanced the accumulation of [3H] vincristine in K562/ADM cells and reversed tumor cell MDR. The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of ...

 相关合成线路
二苯甲酮结构式

119-61-9

二苯甲酮

~%

4-二苯基亚甲基哌啶结构式

50706-57-5

4-二苯基亚甲基哌啶

1-甲基-4-氯哌啶结构式

5570-77-4

1-甲基-4-氯哌啶

~%

4-二苯基亚甲基哌啶结构式

50706-57-5

4-二苯基亚甲基哌啶

4-(bis(4-fluorophenyl)methylene)-1-methylpiperidine结构式

1028316-72-4

4-(bis(4-fluoro...

~%

4-(双(4-氟苯基)亚甲基)哌啶结构式

58113-36-3

4-(双(4-氟苯基)亚甲基)哌啶

1-甲基-4-氯哌啶结构式

5570-77-4

1-甲基-4-氯哌啶

~%

4-(双(4-氟苯基)亚甲基)哌啶结构式

58113-36-3

4-(双(4-氟苯基)亚甲基)哌啶

4,4'-二氟二苯甲酮结构式

345-92-6

4,4'-二氟二苯甲酮

~%

4-(双(4-氟苯基)亚甲基)哌啶结构式

58113-36-3

4-(双(4-氟苯基)亚甲基)哌啶

哌嗪结构式

110-85-0

哌嗪

二苯并环庚烯酮基氯结构式

1210-33-9

二苯并环庚烯酮基氯

~85%

1-(二苯基环庚基)-哌嗪结构式

69159-50-8

1-(二苯基环庚基)-哌嗪

1-甲基-4-氯哌啶结构式

5570-77-4

1-甲基-4-氯哌啶

二苯甲酮结构式

119-61-9

二苯甲酮

~%

(N-Methyl piperidylene-4) diphenyl methane [French]结构式

6071-93-8

(N-Methyl piper...