Asymmetric Syntheses of 2??(1??Aminoethyl) phenols

…, G Lemercier, P Romanens, L Saudan…

文献索引：Kuendig, E. Peter; Botuha, Candice; Lemercier, Gilles; Romanens, Patrick; Saudan, Lionel; Thibault, Sylvie Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 561 - 579

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被引用次数: 28

摘要

Abstract Three different routes were probed for the synthesis of enantiomerically enriched 2- (1-aminoethyl) phenols and their methyl ethers. The first route centers on diastereoselective nucleophile addition to chiral imines. The second route has as key steps the enantioselective reduction of a ketone followed by nucleophilic substitution, and the third route involves a diastereoselective imine reduction. The efficiency of the approach ...

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