Highly Enantioselective Synthesis of β??Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β??Enamino Esters

HJ Zheng, WB Chen, ZJ Wu, JG Deng…

文献索引：Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867

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被引用次数: 71

摘要

Optically active β-amino acids are very important chiral building blocks for the synthesis of β- peptides, β-lactams, natural products, and physiologically active substances.[1] Therefore, efficient methods for the synthesis of optically active β-amino acids would be of great value for drug discovery and organic synthesis. Among the approaches to chiral β-amino acids,[2] the most straightforward and atom economic one is catalytic asymmetric reduction of β- ...