Catalyst and solvent-free amidation of inactive esters of N-protected amino acids

KC Nadimpally, K Thalluri, NB Palakurthy, A Saha…

文献索引：Nadimpally, Krishna Chaitanya; Thalluri, Kishore; Palakurthy, Nani Babu; Saha, Abhijit; Mandal, Bhubaneswar Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2579 - 2582

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被引用次数: 16

摘要

Abstract A catalyst free procedure for the preparation of amides from inactive esters of N- protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.

~70%

~73%

1205-08-9

N-苯甲酰基甘氨酸甲酯

~81%

~82%

~67%

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